tolbutamide

[ tol-byoo-tuh-mahyd ]

noun

, Pharmacology.

1. a white crystalline substance, C 12 H 18 N 2 O 3 S, used to augment insulin secretion in the treatment of diabetes mellitus.

tolbutamide

/ tɒlˈbjuːtəˌmaɪd /

noun

1. a synthetic crystalline compound administered orally in the treatment of diabetes to lower blood glucose concentrations. Formula: C 12 H 18 N 2 O 3 S

Word History and Origins

Origin of tolbutamide¹

First recorded in 1955–60; tol(u) + but(yl) + amide

Word History and Origins

Origin of tolbutamide¹

C20: from tol ( uyl ) + but ( yric acid ) + amide

Example Sentences

Metformin reduced the risk of dying from heart attack and stroke by about 30 percent to 40 percent compared with other commonly used drugs called sulfonylureas, such as glibenclamide, glimepiride, glipizide and tolbutamide, researchers report.

From US News

The headline appeared almost exactly 35 years ago, on July 4, 1975, about a different drug for Type 2 diabetes that went through a strikingly similar controversy: tolbutamide.

From New York Times