tolbutamide

American  

[tol-byoo-tuh-mahyd] / tɒlˈbyu təˌmaɪd /

noun

Pharmacology.

1. a white crystalline substance, C 12 H 18 N 2 O 3 S, used to augment insulin secretion in the treatment of diabetes mellitus.

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tolbutamide British  

/ tɒlˈbjuːtəˌmaɪd /

noun

1. a synthetic crystalline compound administered orally in the treatment of diabetes to lower blood glucose concentrations. Formula: C 12 H 18 N 2 O 3 S

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Etymology

Origin of tolbutamide

First recorded in 1955–60; tol(u) + but(yl) + amide

Example Sentences

Even with these exclusions, indications are that tolbutamide could control diabetes in approximately half the estimated 3,000,000 U.S. cases.

From Time Magazine Archive

Dr. Robert F. Bradley Jr. of Boston's famed Joslin Clinic, reporting on 1,000 patients intensively studied, said tolbutamide gave good control in 55% and fair control in 14%.

From Time Magazine Archive

The study, which followed 823 diabetics for eight years, found that the death rate from cardiovascular diseases was twice as high among patients on tolbutamide as it was among those on insulin treatments or placebos.

From Time Magazine Archive

As a result, the FDA recommended that tolbutamide be used only in cases in which the established treatments?dieting and insulin injections?had proved ineffective.

From Time Magazine Archive

The Food and Drug Administration jumped into a medical dispute this fall when it warned doctors to restrict their use of tolbutamide, an orally administered antidiabetes drug.

From Time Magazine Archive