synthetase

[ sin-thuh-teys, -teyz ]

noun

, Biochemistry.

1. ligase.

Word History and Origins

Origin of synthetase¹

First recorded in 1947; synthet(ic) + -ase

Example Sentences

First, the researchers purified the glutamine synthetase -- the enzyme responsible for the energy-dependent uptake of nitrogen -- from both organisms and checked its activity.

From Science Daily

The researchers decided to try out 2-oxoglutarate, which has been shown to boost the activity of glutamine synthetase in some archaea.

From Science Daily

"We had found a way to turn on the switch for the enzyme's activity in M. thermolithotrophicus, and we even managed to regulate it by manipulating the concentration of 2-oxoglutarate: When the cell needs nitrogen, the 2-oxoglutarate levels increase and switch on the glutamine synthetase. However, when the cell has enough nitrogen, the 2-oxoglutarate levels decrease to a concentration that is insufficient to maintain the enzyme active, preventing nitrogen assimilation. Thus, no energy is wasted when the cell is well-supplied with nitrogen."

From Science Daily

"Mechanistically, we found that this was from low expression of asparagine synthetase, a quality that was distinct from other similar types of leukemia."

From Science Daily

The chemical similarities between DAP, serine and cysteine amino-acid residues made it difficult for the authors to engineer an amino acyl-tRNA synthetase that selectively loads only the ncAA.

From Nature