ligase

[ lahy-geys, -geyz ]

noun

, Biochemistry.

1. any of a class of enzymes that catalyze the joining of two molecules by formation of a covalent bond accompanied by the hydrolysis of ATP.

ligase

/ ˈlaɪˌɡeɪz /

noun

1. any of a class of enzymes that catalyse the formation of covalent bonds and are important in the synthesis and repair of biological molecules, such as DNA

Word History and Origins

Origin of ligase¹

1961; < Latin lig ( āre ) to tie, bind + -ase

Example Sentences

To explore if the elongation of RNA, achieved by linking individual RNA units together, is regulated allosterically, the researchers altered the structure of the R3C ligase.

From Science Daily

For this, they designed an artificial ribozyme, R3C ligase, to investigate how individual RNA units come together to form a functional structure.

From Science Daily

Giving further insight into their work published on 17 April 2024, in Life, Prof. Tamura states, "The R3C ligase is a ribozyme that catalyzes the formation of a 3',5'-phosphodiester linkage between two RNA molecules. We modified the structure by adding specific domains that can interact with various effectors."

From Science Daily

The team noted that R3C ligase activity was dependent on the concentration of ATP, with higher activity observed at higher concentrations of ATP.

From Science Daily

This research demonstrated that a network involving HCR3/J3/HSP40 co-chaperone and the chaperone HSP70 controls crossover interference and localization by facilitating the degradation of the pro-crossover protein, HEI10 ubiquitin E3 ligase.

From Science Daily