Advertisement
Advertisement
ethionamide
[ eth-ee-on-uh-mahyd ]
noun
- an antimicrobial substance, C 8 H 10 N 2 S, used against susceptible Mycobacterium tuberculosis in combination with other drugs in the treatment of any active form of tuberculosis.
Word History and Origins
Origin of ethionamide1
Example Sentences
Thus, they not only attack the pathogen's virulence factors, but also enhance the activity of monooxygenases -- enzymes required for the activation of the conventional antibiotic ethionamide.
Ethionamide is a drug that has been used for many decades to treat TB.
The research has been published in the article 'Discovery of dual-active ethionamide boosters inhibiting the Mycobacterium tuberculosis ESX-1 secretion system' in Cell Chemical Biology.
To reduce the likelihood of M. tuberculosis developing a mutation in the ethA2 gene to again outwit the drug, the authors suggest pulsing doses of SMARt-420 during continual ethionamide treatment.
Déprez suggests that if SMARt-420 increases ethionamide potency in humans, the drug pairing might ultimately reduce the amount of ethionamide needed to treat TB, potentially reducing side effects.
Advertisement
Advertisement
Advertisement
Advertisement
Browse