trimethoprim

[ trahy-meth-uh-prim ]

noun

, Pharmacology.

1. a synthetic crystalline compound, C 11 H 18 N 4 O 3 , usually combined with a sulfonamide as an antibiotic preparation in the treatment of urinary tract infections and pneumocystis pneumonia.

Word History and Origins

Origin of trimethoprim¹

1960–65; trimetho(xyphenyl) + p(y)rim(idinediamine) , components of its chemical name

Example Sentences

Amoxicillin and Trimethoprim are commonly prescribed antibiotics that certain strains of P. aeruginosa have become resistant to.

From Science Daily

However, the UK also uses the antibiotic trimethoprim more often, but analysis did not uncover higher levels of resistance in the UK when comparing the common E. coli strains found in both countries.

From Science Daily

Led by SFI External Professor Andreas Wagner, the researchers experimentally mapped more than 260,000 possible mutations of an E. coli protein that is essential for the bacteria's survival when exposed to the antibiotic trimethoprim.

From Science Daily

Over the course of thousands of highly realistic digital simulations, the researchers then found that 75% of all possible evolutionary paths of the E. coli protein ultimately endowed the bacteria with such a high level of antibiotic resistance that a clinician would no longer give the antibiotic trimethoprim to a patient.

From Science Daily

For years, the urologist alternated between Macrodantin and Trimethoprim.

From Seattle Times