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sphingosine
[ sfing-guh-seen, -sin ]
noun
- a basic unsaturated amino alcohol, C 1 8 H 3 3 (OH) 2 NH 2 , produced by the hydrolysis of sphingomyelin or gangliosides.
sphingosine
/ -ˌsiːn; ˈsfɪŋɡəsɪn /
noun
- biochem a long-chain compound occurring in sphingomyelins and cerebrosides, and from which it can be released by hydrolysis. Formula: CH 3 (CH 2 ) 12 CH:CHCH(OH)CH(NH 2 )CH 2 OH
Word History and Origins
Origin of sphingosine1
Word History and Origins
Origin of sphingosine1
Example Sentences
The study also opens new avenues on how the B12-TCN2-CD320 pathway is regulated by sphingolipids, specifically sphingosine, a naturally occurring and endogenous structural analog of fingolimod, toward improving future MS therapies, Chun said.
Previous work12 has shown that a different lipid mediator that acts on endothelial cells, the molecule sphingosine 1-phosphate, induces the formation of adherens junctions and promotes the development of blood vessels.
Ceramides, which are composed of a sphingosine and a fatty acid, oppose many of the effects of adiponectin.
Sphingosine, the breakdown product of ceramide, exerted adiponectin-like effects and inhibited apoptosis, which suggests that ceramidase activity, not AMPK, is central to AdipoR signaling.
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