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sphingosine

[ sfing-guh-seen, -sin ]

noun

, Biochemistry.
  1. a basic unsaturated amino alcohol, C 1 8 H 3 3 (OH) 2 NH 2 , produced by the hydrolysis of sphingomyelin or gangliosides.


sphingosine

/ -ˌsiːn; ˈsfɪŋɡəsɪn /

noun

  1. biochem a long-chain compound occurring in sphingomyelins and cerebrosides, and from which it can be released by hydrolysis. Formula: CH 3 (CH 2 ) 12 CH:CHCH(OH)CH(NH 2 )CH 2 OH
“Collins English Dictionary — Complete & Unabridged” 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012
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Word History and Origins

Origin of sphingosine1

1881; earlier sphingosin, equivalent to sphingo-, combining form representing Greek sphínx sphinx + intrusive -s- + -in 2; so called in allusion to the enigmas it posed for its discoverer
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Word History and Origins

Origin of sphingosine1

from sphingos- , from Greek sphingein to hold fast + -ine ²
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Example Sentences

The study also opens new avenues on how the B12-TCN2-CD320 pathway is regulated by sphingolipids, specifically sphingosine, a naturally occurring and endogenous structural analog of fingolimod, toward improving future MS therapies, Chun said.

Previous work12 has shown that a different lipid mediator that acts on endothelial cells, the molecule sphingosine 1-phosphate, induces the formation of adherens junctions and promotes the development of blood vessels.

From Nature

Ceramides, which are composed of a sphingosine and a fatty acid, oppose many of the effects of adiponectin.

Sphingosine, the breakdown product of ceramide, exerted adiponectin-like effects and inhibited apoptosis, which suggests that ceramidase activity, not AMPK, is central to AdipoR signaling.

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