proton pump inhibitor

[ proh-ton puhmp in-hib-i-ter ]

noun

, Pharmacology.

1. any of a group of drugs that reduce the production of gastric acid, thereby alleviating acid reflux; promoting the healing of ulcers in the stomach, duodenum, and esophagus; and preventing new ulcers from forming. : PPI

proton-pump inhibitor

noun

1. any of a group of drugs used to treat excessive secretion of acid in the stomach and any resulting ulcers. They block the enzyme (proton pump) in the cells of the gastric glands that secrete hydrochloric acid

Word History and Origins

Origin of proton pump inhibitor¹

First recorded in 1980–85

Example Sentences

Some physicians encourage patients to take this herbal medicine if they experience rebound reflux when discontinuing a proton pump inhibitor such as esomeprazole, lansoprazole or omeprazole.

From Seattle Times

Fortunately, there is a way to offset the risk of bleeding from aspirin: by prescribing a proton pump inhibitor, a class of drugs that reduces the amount of acid, which can contribute to bleeding, produced by the stomach.

From Time

But he says it might be worth discussing with your doctor whether adding a proton pump inhibitor would make sense to protect you from the potentially dangerous side effects of bleeding.

From Time

If adopting the above measures fails to fully control acid reflux, taking a proton pump inhibitor may also be needed.

From New York Times

Holly M. Holmes, chair of the Division of Geriatric and Palliative Medicine at McGovern Medical School at University of Texas Health Science Center at Houston, says patients are often prescribed a proton pump inhibitor while in the hospital to treat a short-term problem with heartburn or reflux, “but then they end up staying on them forever.”

From Wall Street Journal