prothrombin

[ proh-throm-bin ]

noun

, Biochemistry.

1. a plasma protein involved in blood coagulation that on activation by factors in the plasma is converted to thrombin.

prothrombin

/ prəʊˈθrɒmbɪn /

noun

1. biochem a zymogen found in blood that gives rise to thrombin on activation See also phylloquinone

prothrombin

/ prō-thrŏm′bĭn /

1. A glycoprotein that is converted to thrombin during blood clotting. Prothrombin is formed by and stored in the liver.

Word History and Origins

Origin of prothrombin¹

First recorded in 1895–1900; pro- ¹ + thrombin

Example Sentences

They found I have a blood disorder called prothrombin gene mutation.

From Fox News

I had barely removed my coat before the doctor started rattling off the things I had tested negative for: antiphospholipid antibodies, lupus anticoagulant, Factor V Leiden, prothrombin gene mutation.

From The Guardian

This is a difficult drug to control, and close monitoring of prothrombin times — a measure of how long it takes a person’s blood to clot — is necessary.

From Washington Post

Wrong prothrombin time results could cause doctors to prescribe too little or too much warfarin.

From Wall Street Journal

Tests showed that she has a prothrombin gene mutation that, with estrogen, is a time bomb.

From Seattle Times