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proband

[ proh-band ]

noun

, Genetics.
  1. a patient who is the initial member of a family to come under study.


proband

/ ˈprəʊbænd /

noun

  1. another name (esp US) for propositus
“Collins English Dictionary — Complete & Unabridged” 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012
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Word History and Origins

Origin of proband1

1925–30; < Latin probandus, gerundive of probāre to test, probe
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Word History and Origins

Origin of proband1

C20: from Latin probandus, gerundive of probāre to test
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Example Sentences

Granddaddy called it the Proband.

For cases in which there is a single affected proband and no family history, investigators should consider sequencing the unaffected parents of the probands, permitting efficient discovery of de novo mutations and compound heterozygous genotypes.

From Nature

Upon further medical evaluation, these mutations were found to account for each proband’s disease, leading to a change in diagnosis, some of which led to changes in patient management.

Australian pedigrees for which the proband was identified as carrying the E318K variant via Sequenom, as well as the panel of melanoma cell lines, were screened for E318K via Sanger sequencing using the following primers: forward, 5′-CAGGCTCGAGCTCATGGA-3′; reverse, 5′- TGGGGACACTATAGGCTTGG-3′.

From Nature

If he fled from his lord's service, or from the land which he held, a writ issued de nativitate proband�, and the master recovered his fugitive by law.

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probablyprobang