Advertisement

Advertisement

metallo-

  1. a combining form representing metal in compound words:

    metallography.



metallo-

combining_form

  1. denoting metal

    metallography

    metallurgy

    metalloid

“Collins English Dictionary — Complete & Unabridged” 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012
Discover More

Word History and Origins

Origin of metallo-1

< Greek, combining form of métallon
Discover More

Word History and Origins

Origin of metallo-1

from Greek metallon
Discover More

Example Sentences

"Fat is a major component of our diet, and eating trans fats is known to drive heart disease. We used this phenomenon to understand the biological mechanisms putting us at risk," says senior author Christian Metallo, professor and holder of the Daniel and Martina Lewis Chair at Salk.

The fate of dietary fat is often determined by the protein that metabolizes it, explains Metallo, so it was important for the Salk team to first explore the metabolic landscape that creates sphingolipids in the first place.

"We found the incorporation of trans fats through SPT increased lipoprotein secretion from the liver, which then promoted the formation of atherosclerotic plaques," says first author Jivani Gengatharan, a postdoctoral researcher in Metallo's lab.

"As we get a better grasp on identifying and measuring these diverse circulating molecules in our bodies and how they're metabolized, we could make huge strides in personalizing medicine accordingly," says Metallo.

"Our results reveal new therapeutic possibilities for immunotherapy-resistant EGFR-driven lung adenocarcinomas," says co-corresponding author Christian Metallo, professor and holder of the Daniel and Martina Lewis Chair at Salk.

Advertisement

Advertisement

Advertisement

Advertisement