Down syndrome

or Down's syndrome

noun

, Pathology.

1. a genetic disorder, associated with the presence of an extra chromosome 21, characterized by mild to severe mental impairment, weak muscle tone, shorter stature, and a flattened facial profile.

Sensitive Note

Down syndrome (or Down's syndrome ) has replaced earlier terms, such as mongolism to refer to the disease and Mongoloid or Mongol to refer to the affected person, all of which are now considered offensive.

Word History and Origins

Origin of Down syndrome¹

First recorded in 1960–65; after John L. H. Down (1828–96), British physician

Example Sentences

During the day she worked as an aide for a girl with Down syndrome, and at night she was a barista at Dutch Bros., her father said.

From Los Angeles Times

Ohio’s ban on abortions because of a Down syndrome diagnosis remains in effect, following a federal court decision in 2021.

From Seattle Times

Some cases also are linked to Down syndrome.

From Seattle Times

His youngest son, Jimmy, was born with Down syndrome, which led Erskine to champion the cause of people with developmental disabilities.

From Seattle Times

Her 17-year-old daughter Dayra, who has Down syndrome and autism, was among the first in the state to enter the fledgling program.

From Los Angeles Times