dornase alfa

[ dawr-neys al-fuh, -neyz ]

1. a genetically engineered form of recombinant human DNase that reduces the viscosity of mucus in the lungs, especially in the treatment of cystic fibrosis.

Word History and Origins

Origin of dornase alfa¹

First recorded in 1980–85; shortening and alteration of (recombinant human) d(e)o(xy)r(ibo)n(ucle)ase (1) + alpha ( def )

Example Sentences

In people with cystic fibrosis—an inherited disease that causes persistent lung infections—a medication called dornase alfa that breaks up NETs by cleaving DNA can loosen sputum and relieve symptoms.

From Scientific American

Additional trials are testing other NET-targeting agents —such as dornase alfa and drugs approved for rheumatoid arthritis and gout—in patients hospitalized for COVID-19.

From Scientific American