degranulation

[ dee-gran-yuh-ley-shuhn ]

noun

1. the loss or elimination of granules.

Word History and Origins

Origin of degranulation¹

First recorded in 1940–45; de- + granulation

Example Sentences

These substances interact with EP3 receptors in MCs and prevent degranulation, limiting the release of histamine and minimizing allergic response.

From Science Daily

This led to changes in the expression levels of the IgE-receptor, which ultimately inhibited degranulation in MCs.

From Science Daily

Additional experiments revealed that non-steroidal anti-inflammatory drugs suppressed the anti-allergic effects of SCFAs, and that vitamin B-3, which interacts with the GPR109A receptor, also inhibited MC degranulation.

From Science Daily

LAT1-dependent calcium signals required for mast cell degranulation were dampened, but the role of LAT2 in chemokine production was enhanced, altering immune cell recruitment at the site of inflammation.

From Science Magazine

In vitro studies demonstrate that serum AAT coordinates TNF-α intracellular signaling and neutrophil degranulation of tertiary and secondary granules via modulation of ligand-receptor interactions.

From Science Magazine