cyclic GMP

noun

, Biochemistry.

1. a cyclic anhydride of guanosine monophosphate formed from guanosine triphosphate by the action of guanylate cyclase: in cellular metabolism, it acts as a second messenger associated with increased cell division and growth.

Word History and Origins

Origin of cyclic GMP¹

First recorded in 1970–75

Example Sentences

For example, it can interact with transition metals such as those in the haem group of guanylyl cyclase enzymes, which produce cyclic GMP — a messenger molecule involved in many biological processes.

From Nature

This enzyme prevents the release of certain neurotransmitters--most notably one called cyclic GMP--that cause the smooth muscles surrounding arteries to relax, allowing the arteries to expand.

From Time Magazine Archive

While PDE5 is always present in the penis, cyclic GMP is produced only during arousal.

From Time Magazine Archive

The catch in impotent men is that they may not produce enough cyclic GMP to temporarily "win out" over the PDE5.

From Time Magazine Archive

Thus the efficacy of Viagra: by strong-arming PDE5, it allows a little bit of one's cyclic GMP to go a long way.

From Time Magazine Archive