BBB

¹

1. Better Business Bureau.

BBB

²

Symbol.

1. a quality rating for a corporate or municipal bond, lower than A and higher than BB.

Example Sentences

"Lack of an authentic human BBB model has been a major hurdle in studying neurological diseases," says lead corresponding author Ziyuan Guo, PhD, "Our breakthrough involves the generation of human BBB organoids from human pluripotent stem cells, mimicking human neurovascular development to produce a faithful representation of the barrier in growing, functioning brain tissue. This is an important advance because animal models we currently use in research do not accurately reflect human brain development and BBB functionality."

From Science Daily

"Now, through stem cell bioengineering, we have developed an innovative platform based on human stem cells that allows us to study the intricate mechanisms governing BBB function and dysfunction. This provides unprecedented opportunities for drug discovery and therapeutic intervention," Guo says.

From Science Daily

The research team calls their new model "BBB assembloids."

From Science Daily

Importantly, the BBB assembloids can be grown using neurotypical human stem cells or stem cells from people with specific brain diseases, thus reflecting gene variants and other conditions that can lead to a malfunctioning blood-brain barrier.

From Science Daily

The co-authors envision a variety of potential uses of BBB assembloids:

From Science Daily