amantadine

[ uh-man-tuh-deen ]

noun

, Pharmacology.

1. a water-soluble crystalline substance, C 10 H 17 NHCl, used as an antiviral and antiparkinsonian drug.

amantadine

/ əˈmæntəˌdiːn /

noun

1. an antiviral drug used in the treatment of some types of influenza and to reduce some of the symptoms of Parkinson's disease

Word History and Origins

Origin of amantadine¹

1960–65; coinage apparently based on the chemical name 1-aminoadamantane; amino-, adamantane

Word History and Origins

Origin of amantadine¹

C20: a blend of amine + adamantane the chemical compound from which it is derived

Example Sentences

What’s more, the flu virus has developed resistance to oseltamivir and to an older drug, amantadine.

From Science Magazine

His main approach has been to target the mutation in the M2 channel that created resistance to amantadine and rimantadine.

From Nature

Amantadine blocks the process by which viral RNA is released into the host cell, and the mutation provides a new channel through which the virus can release its RNA.

From Nature

Nearly all the viruses in circulation around the globe had a mutation that rendered amantadine and rimantadine — the two adamantanes used to treat flu, which work by blocking a particular step in viral replication — completely useless.

From Nature

Extended-release amantadine, taken daily, has been shown to reduce the total daily OFF time but does not convert an OFF episode into ON time.

From Scientific American