active site

noun

, Biochemistry.

1. the part of an enzyme that interacts with the substrate during catalysis.

active site

1. The part of an enzyme where the catalytic activity on the substrate takes place.
2. See more at enzyme

active site

1. The part of an enzyme or antibody where a chemical reaction occurs.

Word History and Origins

Origin of active site¹

First recorded in 1960–65

Example Sentences

The free radical generated from photochemistry comes into play here, entering the enzyme active site and engaging the enzymatic intermediate to enable new chemistry.

From Science Daily

ATP is the central energy carrier of the cell which supports numerous molecular processes, while, histidine is the most common amino acid found in the active site of enzymes, and maintains their acid-base chemistry.

From Science Daily

The model allowed them to identify a protein that interacts with the DNA as it is being transcribed and guides it to the enzyme's active site.

From Science Daily

The drugs work by attaching to a pocket adjacent to the active site, inducing an allosteric conformational change in the protein that prevents it from being activated.

From Science Daily

Forest Service stipulates that the observatory must remain an active site for research, astronomy or education — or be dismantled down to its last historic bolt.

From Los Angeles Times