hypertrophy

[ hahy-pur-truh-fee ]

noun

, plural hy·per·tro·phies.

1. abnormal enlargement of a part or organ; excessive growth. Compare gigantism ( def 1 ).
2. excessive growth or accumulation of any kind.

verb (used with or without object)

, hy·per·tro·phied, hy·per·tro·phy·ing.

1. to affect with or undergo hypertrophy.

hypertrophy

/ ˌhaɪpəˈtrɒfɪk; haɪˈpɜːtrəfɪ /

noun

1. enlargement of an organ or part resulting from an increase in the size of the cells Compare atrophy hyperplasia

verb

1. to undergo or cause to undergo this condition

Derived Forms

• hypertrophic, adjective

Other Words From

• hy·per·troph·ic [hahy-per-, trof, -ik, -, troh, -fik], adjective

Word History and Origins

Origin of hypertrophy¹

First recorded in 1825–35; hyper- + -trophy

Example Sentences

For example, the diabetic human heart organoids were larger, suggesting signs of cardiac hypertrophy -- a first hallmark of maternal pregestational diabetes.

From Science Daily

Surgery for benign prostatic hypertrophy “is no big deal,” he said.

From New York Times

Cells started to increase their size, a phenomenon known as hypertrophy that is commonly seen in alveolar injury in vivo, the barrier comprised by tightly packed endothelial and epithelial cells started to break down and liquid flowed through the endothelial channel accumulated in the epithelial channel.

From Science Daily

"We found that further increasing HMOX1 levels with the drug lovastatin in the Lung Alveolus Chip reduced DNA damage and cellular hypertrophy early after the radiation, similarly to the anti-inflammatory drug prednisolone, which we used as a positive control. Later, however, lovastatin worsened the disruption of the endothelial barrier. In fact, by experimentally knocking down HMOX1 expression during later stages, we could partially reverse its later adverse effects," explained Dasgupta.

From Science Daily

Other investigators are analyzing the data to determine how effective testosterone treatment is at alleviating the symptoms of hypogonadism, which include depression, osteoporosis, anemia, loss of muscle mass and a bothersome condition called benign prostatic hypertrophy, which blocks the flow of urine, in addition to sexual symptoms.

From New York Times