non-nucleoside

[ non-noo-klee-uh-sahyd, -nyoo- ]

noun

, Pharmacology.

1. any of various antiviral drugs that bind directly to reverse transcriptase and prevent RNA conversion to DNA, used in combination with other drugs to treat HIV infection.

Example Sentences

The paper — titled “In silico screening for potential COVID-19 beta-coronavirus non-nucleoside RdRp inhibitors” — was posted on the website of “Prospero Pharmaceuticals,” which identifies itself as a biotech company that’s “developing therapies for unmet medical needs in orphan diseases.”

From Fox News

Bristol early next year plans to begin Phase III testing of an all-oral, three-drug combination that adds BMS791325 - a non-nucleoside polymerase inhibitor - to the two drugs tested in the Japanese study.

From Reuters

Drug resistance was serious only in eastern and southern Africa, and mostly involved a class of medications called non-nucleoside reverse transcriptase inhibitors.

From New York Times

They show that non-nucleoside reverse transcriptase inhibitors and protease inhibitors exhibit cooperative dose-response curves—a finding that has implications for the treatment of HIV as well as other viral infections, such as hepatitis C.

From Science Magazine