mast cell

noun

, Biology.

1. a large granular cell, common in connective tissue, that produces heparin, histamine, and serotonin.

mast cell

noun

1. a type of granular basophil cell in connective tissue that releases heparin, histamine, and serotonin during inflammation and allergic reactions

mast cell

/ măst /

1. A granular cell found in body tissue, especially connective tissue, that activates inflammation by releasing a variety of chemical substances including histamine, tumor necrosis factor, and interleukins. Mast cells have membrane receptors that bind to bacteria, triggering the release of inflammatory mediators from the mast cell's cytoplasmic granules. Mast cells also play an important role in allergic reactions. Other receptors on their membranes bind to specific antibodies that, combined with certain antigens, initiate granular release of chemical mediators that cause allergic signs and symptoms.

Word History and Origins

Origin of mast cell¹

1885–90; partial translation of German Mastzelle, equivalent to Mast fattening of animals for slaughter, mast ² + Zelle cell

Word History and Origins

Origin of mast cell¹

C19: from mast ², on the model of German Mastzelle

Example Sentences

The cost was due to the “unfortunate confluence,” she said, of the dog needing ACL surgery and then developing mast cell cancer.

From Los Angeles Times

These include cancers of the lymph nodes, bones, blood vessels or mast cell tumors for some breeds; and joint disorders such as hip or elbow dysplasia, or cranial cruciate ligament tears.

From Science Daily

The study explored a rare form of mast cells called myeloid progenitors in blood, in patients with the condition.

From Science Daily

Thereafter, even low levels of those and other unrelated substances can cause the mast cells to release the mediators that can lead to inflammation and illness.

From Science Daily

Ms. Banks had mast cell activation syndrome, a disorder of the immune system, and had been unable to undergo standard cancer treatments or take most medications, including those for pain.

From New York Times