Klinefelter syndrome

American  

[klahyn-fel-ter sin-drohm, ‐druhm] / ˈklaɪn fɛl tər ˈsɪn droʊm, ‐drəm /

noun

Pathology.

1. an abnormal condition in which at least one extra X chromosome is present in a male: characterized by reduced or absent sperm production, small testicles, and in some cases enlarged breasts. KS

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Etymology

Origin of Klinefelter syndrome

First recorded in 1945–50; named after Harry Fitch Klinefelter (1912–90), U.S. physician, coauthor of a description of the syndrome

Example Sentences

The three individuals with Klinefelter syndrome lived across very different time periods, but they shared some similarities -- all were slightly taller than average and showed signs of delayed development in puberty.

From Science Daily • Jan. 11, 2024

More complex types of Klinefelter syndrome exist in which the individual has as many as five X chromosomes.

From Textbooks • Jun. 9, 2022

Now a chronic fear of running out compounds her worries, and a poor diet aggravates her son’s struggles with autism and Klinefelter syndrome, a genetic disorder that leads to violent outbursts.

From Seattle Times • Aug. 15, 2021

The XXY chromosome complement, corresponding to one type of Klinefelter syndrome, corresponds to male individuals with small testes, enlarged breasts, and reduced body hair.

From Textbooks • Apr. 25, 2013

Men born with Klinefelter syndrome, a rare condition where men have an extra X chromosome, may be more susceptible to breast cancer, as well as men who inherit a mutated gene.

From Washington Post • Feb. 25, 2013