immunocompromised

American  

[im-yuh-noh-kom-pruh-mahyzd] / ˌɪm yə noʊˈkɒm prə maɪzd /

immune-compromised,

adjective

1. having a compromised or impaired immune response; immunodeficient.

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immunocompromised British  

/ ˌɪmjʊnəʊˈkɒmprəmaɪzd /

adjective

1. having an impaired immune system and therefore incapable of an effective immune response, usually as a result of disease, such as AIDS, that damages the immune system

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Etymology

Origin of immunocompromised

First recorded in 1970–75; immuno- + compromised

Example Sentences

Doctors and researchers agree that one dose is fine in adolescents, but two to three doses are still recommended in older and immunocompromised populations.

From Salon • Feb. 22, 2026

What if I’m unvaccinated because I’m severely immunocompromised?

From Slate • Feb. 17, 2026

Rob Davis notes the severity of the current flu season, as well as a population of 85 million people who are high risk or immunocompromised and 25 million people over 65.

From The Wall Street Journal • Jan. 13, 2026

Standard vaccines are often less effective in older people or in the immunocompromised because they work through the immune system.

From Barron's • Nov. 14, 2025

Wasn’t the mom with cancer supposed to be home, in isolation, immunocompromised?

From "Not Nothing" by Gayle Forman