fumarate

[ fyoo-muh-reyt ]

noun

, Biochemistry.

1. the salt of fumaric acid, a key chemical intermediate in the Krebs cycle.

fumarate

/ fyo̅o̅′mə-rāt′ /

1. A salt or ester of fumaric acid, in which one or both of the hydrogen atoms in the carboxyl groups of the fumaric acid have been replaced with another element or group.

Word History and Origins

Origin of fumarate¹

First recorded in 1860–65; fumar(ic acid) + -ate ²

Example Sentences

Fumarate and succinate, for example, are formed as intermediate products in the mitochondria of cells.

From Science Daily

Now, a team at HZB led by Prof. Alexander Föhlisch has elucidated the influence of the electronic structure on the stability of fumarate, maleate and succinate dianions.

From Science Daily

The analysis of the spectral data shows that maleate is potentially less stable than fumarate and succinate.

From Science Daily

The Recovery trial currently has experiments under way in more than 38,000 patients on five drugs: aspirin; colchicine, a gout treatment; a COVID-19-targeted antibody cocktail made by Regeneron Pharmaceuticals; baricitinib, which treats rheumatoid arthritis; and dimethyl fumarate, a treatment for multiple sclerosis,” Kupferschmidt writes.

From Scientific American

The trial has randomized more than 38,000 participants and is testing five drugs: aspirin; colchicine, a gout treatment; a COVID-19–targeted antibody cocktail made by Regeneron Pharmaceuticals; baricitinib, which treats rheumatoid arthritis; and dimethyl fumarate, a treatment for multiple sclerosis.

From Science Magazine