Showing results for downregulation. Search instead for down-regulation.

downregulation

British

/ ˌdaʊnrɛɡjʊˈleɪʃən /

noun

a decrease in sensitivity, through overexposure, to a drug or other chemical caused by a reduction in the number or density of receptors on cell surfaces

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

Furthermore, the researchers examined the effect of Gprc5a downregulation on osteoblast proliferation and differentiation.

From Science Daily • Jun. 18, 2024

Researchers found that early stage melanomas which are at risk of spreading secrete a growth factor which causes the reduction, or downregulation, of certain proteins in the skin overlying the tumour.

From BBC • Jan. 14, 2022

Induction of sgRNA2b resulted in downregulation of pluripotency genes such as NANOG, ETS1 and DPPA3, consistent with OCT4 depletion causing exit from self-renewal.

From Nature • Sep. 19, 2017

This process is called downregulation, and it allows cells to become less reactive to the excessive hormone levels.

From Textbooks • Jun. 19, 2013

Thus, their downregulation, or reduction in response, would allow the content of the limbic systems that process emotion and perhaps sensory cortices to play a relatively more dominant role.

From Scientific American • May 15, 2012

Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023