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major depressive disorder

American

[may-jer-di-pres-iv-dis-awr-der] / ˈmeɪ dʒər dɪˈprɛs ɪv dɪsˈɔr dər /

noun

Psychiatry. an affective disorder characterized by a sustained period of low mood, diminished self-esteem, and reduced interest in normally enjoyable activities.

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

Earlier studies have shown that people diagnosed with major depressive disorder have lower levels of Reelin in their brains.

From Science Daily • Feb. 2, 2026

Biohaven tumbles after its drug, BHV-7000, fails to meet the primary endpoint in a phase 2 trial for major depressive disorder.

From Barron's • Dec. 26, 2025

Antidepressants are typically prescribed for people with major depressive disorder.

From The Wall Street Journal • Nov. 11, 2025

Behind its glassy doors is something rare: A community run by people with serious mental health conditions such as schizophrenia, bipolar disorder and major depressive disorder.

From Los Angeles Times • Nov. 2, 2024

At one point, Crooks searched "major depressive disorder" on one of his cellphones.

From Salon • Jul. 18, 2024

Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023