osteogenesis imperfecta

American  

[im-per-fek-tuh] / ˌɪm pərˈfɛk tə /

noun

Pathology.

1. a rare hereditary disease in which abnormal connective tissue development leads to fragile bones subject to fracture.

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osteogenesis imperfecta British  

/ ˌɪmpəˈfɛktə /

noun

1. Also called: brittle bone syndrome.  a hereditary disease caused by a collagen abnormality, causing fragility of the skeleton which results in fractures and deformities

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osteogenesis imperfecta Scientific  

/ ŏs′tē-ə-jĕn′ĭ-sĭsĭm′pər-fĕk′tə /

1. A hereditary disease characterized by abnormally brittle, easily fractured bones.

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Etymology

Origin of osteogenesis imperfecta

1900–05; < New Latin: imperfect osteogenesis

Example Sentences

The two biotechs are partners, as they are collaborating in the development of setrusumab for the treatment of osteogenesis imperfecta — a rare genetic bone metabolism disorder known as brittle-bone disease.

From MarketWatch • Dec. 29, 2025

The companies said two Phase 3 trials for setrusumab to treat osteogenesis imperfecta, a rare bone disorder, didn’t meet their main goal of reducing fracture rates.

From Barron's • Dec. 29, 2025

Em was born with osteogenesis imperfecta, also known as brittle bone disease, so her family has treated her delicately her entire life.

From Los Angeles Times • Jun. 18, 2025

I have lived with osteogenesis imperfecta my entire life and am a full-time wheelchair user.

From Salon • Apr. 1, 2025

She has osteogenesis imperfecta, better known as brittle bones, is short of stature and uses a wheelchair.

From BBC • Jul. 22, 2022