cyclosporine

American  

[sahy-kluh-spawr-een, -in, -spohr-, sik-luh-] / ˌsaɪ kləˈspɔr in, -ɪn, -ˈspoʊr-, ˌsɪk lə- /

Also cyclosporin

noun

Pharmacology.

1. a substance, synthesized by certain soil fungi, that suppresses the immune response by disabling helper T cells, used to minimize rejection of foreign tissue transplants.

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cyclosporine Scientific  

/ sī′klə-spôr′ēn,-ĭn /

1. A polypeptide obtained from any of various deuteromycete fungi, used as an immunosuppressive drug to prevent the rejection of transplanted organs.

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Etymology

Origin of cyclosporine

1975–80; < New Latin Cyclospor ( eae ) a class of brown algae ( see cyclo-, -spore, -eae) + -in ²

Example Sentences

Then, in the early 1970s, Dr. Calne learned of a new drug, cyclosporine.

From New York Times • Jan. 15, 2024

He helped develop the breakthrough anti-rejection drug cyclosporine and was the first physician to administer it to transplant patients.

From Seattle Times • Jan. 7, 2024

Design an experiment to test the use of conditioning using the administration of cyclosporine as the unconditioned stimulus and sugar water as the conditioned stimulus by measuring the blood concentration of interleukin.

From Textbooks • Jun. 9, 2022

Isolated from a soil fungus found in Africa, cyclosporine was synthesized as an immunosuppressant by the pharmaceutical company Sandoz in 1980, and after wide testing was released into the market in 1983.

From Washington Post • Sep. 30, 2019

Because they dampen the body’s disease-fighting systems, drugs most commonly used, cyclosporine and tacrolimus, are associated with infections, tumors and kidney damage, Sher said.

From BusinessWeek • Jan. 17, 2011