cycloaddition

[ sahy-kloh-uh-dish-uhn, sik-loh- ]

noun

, Chemistry.

1. the formation of a cyclic compound by the addition reaction of unsaturated molecules.

Word History and Origins

Origin of cycloaddition¹

First recorded in 1960–65; cyclo- + addition

Example Sentences

This intermediate step is crucial, as Nagashima remarks: "Our detailed mechanistic studies revealed that the photoexcited borate complex both accelerates the cycloaddition and suppresses the rearomatization that usually occurs in conventional photocycloaddition reactions."

From Science Daily

"We first had to change their specific bonding structure -- carrying out so-called dearomatization -- in order to obtain significantly more reactive intermediates. The subsequent cycloaddition and rearomatization processes ultimately result in the formation of the skeletal-edited compounds."

From Science Daily

The reaction is called copper-catalyzed azide-alkyne cycloaddition -- abbreviated CuAAC and pronounced "quack."

From Science Daily

Later, independently of each other, Meldal and Sharpless discovered “what is now the crown jewel of click chemistry: the copper-catalyzed azide-alkyne cycloaddition. This is an elegant and efficient chemical reaction that is now in widespread use,” the academy said.

From Science Magazine

Later, Meldal and Sharpless, independently of each other, discovered “what is now the crown jewel of click chemistry: the copper catalysed azide-alkyne cycloaddition. This is an elegant and efficient chemical reaction that is now in widespread use.”

From Science Magazine