allosteric

American  

[al-uh-ster-ik, -steer-] / ˌæl əˈstɛr ɪk, -ˈstɪər- /

adjective

Biochemistry.

1. pertaining to regulation of the rate of an enzymatic process.

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allosteric British  

/ ˌæləʊˈstɪərɪk /

adjective

1. biochem of, relating to, or designating a function of an enzyme in which the structure and activity of the enzyme are modified by the binding of a metabolic molecule

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Other Word Forms

• allosterically adverb

Etymology

Origin of allosteric

First recorded in 1960–65; allo- + steric

Example Sentences

Researchers at the Centre for Genomic Regulation in Barcelona, Spain, and the Wellcome Sanger Institute near Cambridge, UK, have comprehensively identified the allosteric control sites found in the protein KRAS.

From Science Daily • Dec. 18, 2023

Drugs that target allosteric sites are generally safer and more effective compared to drugs targeting active sites.

From Science Daily • Dec. 18, 2023

The study provides the first ever complete map of allosteric sites for any complete protein in any species.

From Science Daily • Dec. 18, 2023

In contrast, in allosteric activation, the activator molecule modifies the shape of the active site to allow a better fit of the substrate.

From Textbooks • Apr. 25, 2013

When an allosteric inhibitor binds to a region on an enzyme, all active sites on the protein subunits are changed slightly such that they bind their substrates with less efficiency.

From Textbooks • Apr. 25, 2013