predisposition
Americannoun
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the fact or condition of being predisposed.
a predisposition to think optimistically.
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Medicine/Medical. tendency to a condition or quality, usually based on the combined effects of genetic and environmental factors.
Other Word Forms
- predispositional adjective
Etymology
Origin of predisposition
First recorded in 1615–25; pre- + disposition
Example Sentences
Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.
Your ideal rise time is linked to your chronotype, your genetic predisposition to waking at a certain time.
From The Wall Street Journal • Jan. 11, 2026
The Oscar-winning actor announced in 2013 that she had undergone a double mastectomy, followed by a double oophorectomy in 2015, due to her genetic predisposition to cancer.
From Barron's • Dec. 15, 2025
Genetic predisposition increases disease risk in certain populations.
From Science Daily • Nov. 17, 2025
They’ve identified some genetic anomalies that lead to a predisposition to the spectrum.
From Los Angeles Times • Apr. 22, 2025
For a while she’d struggled against her predisposition.
From "Middlesex: A Novel" by Jeffrey Eugenides
Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023
Idioms from The American Heritage® Idioms Dictionary copyright © 2002, 2001, 1995 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company.
