Paget's disease

American  

noun

1. Pathology. a chronic disease characterized by episodic accelerated bone resorption and growth of abnormal replacement bone, causing bone pain, deformation, fractures, and osteosarcoma; osteitis deformans.

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Paget's disease British  

/ ˈpædʒɪts /

noun

1. Also called: osteitis deformans.  a chronic disease of the bones characterized by inflammation and deformation

2. Also called: Paget's cancer.  cancer of the nipple and surrounding tissue

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Paget's disease Scientific  

/ păj′ĭts /

1. A disease, occurring chiefly in the elderly, in which the bones become enlarged and weakened, often resulting in fracture or deformity.

2. A breast cancer manifested by inflammatory changes of the nipple and surrounding skin.

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Etymology

Origin of Paget's disease

1875–80; named after Sir James Paget, who described it

Example Sentences

Begg and his colleagues scanned the composer’s genome for several conditions linked to hearing loss, including Paget’s disease and lupus.

From Scientific American • Mar. 23, 2023

In Paget’s disease, new bone is formed in an attempt to keep up with the resorption by the overactive osteoclasts, but that new bone is produced haphazardly.

From Textbooks • Jun. 19, 2013

Bisphosphonates, drugs that decrease the activity of osteoclasts, are often used in the treatment of Paget’s disease.

From Textbooks • Jun. 19, 2013

Osteoporosis does not have the elevated blood levels of alkaline phosphatase found in Paget’s disease.

From Textbooks • Jun. 19, 2013

Paget's disease of the nipple is an epithelioma occurring in women over forty years of age: a similar form of epithelioma is sometimes met with at the umbilicus or on the genitals.

From Manual of Surgery Volume First: General Surgery. Sixth Edition. by Thomson, Alexis