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Benadryl

American  
[ben-uh-dril] / ˈbɛn ə drɪl /
Pharmacology, Trademark.
  1. a brand of diphenhydramine.


Benadryl British  
/ ˈbɛnədrɪl /

noun

  1. an antihistamine drug used in sleeping tablets; diphenhydramine. Formula: C 17 H 21 NO

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

Sales rose 1.5% in Kenvue’s self care business, which includes products such as Tylenol and Benadryl.

From The Wall Street Journal • Feb. 17, 2026

When the boy developed the rash, his family gave him the antihistamine Benadryl and soaked him in a bath at home, but it did not go away, according to Madisonville police.

From Seattle Times • Apr. 11, 2024

A few weeks ago, a jail physician stopped prescribing Jessie his antipsychotic medicine, Haldol, instead prescribing only Benadryl for sleep and another medicine for anxiety, Roblero said.

From Los Angeles Times • Dec. 22, 2023

Classic brand names like Benadryl, Claritin, Allegra, and Zyrtec are antihistamines, which can be used to treat, or lessen, that histamine reaction and thus the itch.

From Slate • Sep. 23, 2023

She’s wearing a pink shirt and holding a bottle of pink Benadryl.

From "The Immortal Life of Henrietta Lacks" by Rebecca Skloot