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ligase

American

[lahy-geys, -geyz] / ˈlaɪ geɪs, -geɪz /

noun

Biochemistry.

any of a class of enzymes that catalyze the joining of two molecules by formation of a covalent bond accompanied by the hydrolysis of ATP.

ligase British

/ ˈlaɪˌɡeɪz /

noun

any of a class of enzymes that catalyse the formation of covalent bonds and are important in the synthesis and repair of biological molecules, such as DNA

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Etymology

Origin of ligase

1961; < Latin lig ( āre ) to tie, bind + -ase

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

This research demonstrated that a network involving HCR3/J3/HSP40 co-chaperone and the chaperone HSP70 controls crossover interference and localization by facilitating the degradation of the pro-crossover protein, HEI10 ubiquitin E3 ligase.

From Science Daily • Mar. 8, 2024

This alteration is recognized by a ubiquitin ligase, thus marking the protein for degradation.

From Science Daily • Feb. 21, 2024

Or, by introducing a kind of "molecular glue" into the cell, which attaches to the ligase and thereby induces it to recognize and mark the unwanted protein for degradation.

From Science Daily • Feb. 21, 2024

DNA ligase stitches together the new foreign gene to the existing piece of DNA.

From Textbooks • Jun. 9, 2022

DNA ligase separates the ends of the new segment, especially the Okazaki fragments.

From Textbooks • Jun. 9, 2022

Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023