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spt.
abbreviation for
- seaport.
spt
abbreviation for
- seaport
Example Sentences
The team suspected that trans fats were being incorporated into sphingolipids by SPT, which, in turn, would promote the excess lipoprotein secretion into the bloodstream that causes ASCVD.
"We found the incorporation of trans fats through SPT increased lipoprotein secretion from the liver, which then promoted the formation of atherosclerotic plaques," says first author Jivani Gengatharan, a postdoctoral researcher in Metallo's lab.
Starting with cells in Petri dishes, the team looked at whether trans or cis fats were preferentially metabolized by SPT -- and it turns out that SPT preferred trans fats.
Furthermore, SPT's bias for trans fats was causing downstream sphingolipid secretion that could go on to cause plaque formation.
To probe these effects further, they inhibited SPT to see whether they could limit negative trans fat effects in mice, finding that reducing SPT activity did decrease trans fat-induced atherosclerosis.
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