proto-oncogene

[ proh-toh-ong-kuh-jeen ]

noun

1. a normally present gene that appears to have a role in the regulation of normal cell growth, but that is converted to an oncogene by mutation.

Example Sentences

Duplications of at least one proto-oncogene involved in mitochondrial health might relate to an improved response to oxidative stress, known to be an important factor in ageing.

From Nature

These data support the hypothesis that the p.L265P mutation constitutes an activating mutation of this novel proto-oncogene.

From Nature

The genetic cause of this form of cancer is known — it is caused by mutations in a structure called the RET proto-oncogene — and genetic testing is commercially available.

From New York Times