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pluripotent
[ ploor-uh-poht-nt ]
adjective
- (of a cell) capable of developing into any type of cell or tissue except those that form a placenta or embryo:
pluripotent stem cells.
pluripotent
/ ˌplʊrɪˈpəʊtənt /
adjective
- biology capable of differentiating into different types of body cell
Other Words From
- pluri·poten·cy noun
Word History and Origins
Origin of pluripotent1
Example Sentences
In this new research, through a set of experiments conducted in collaboration with Dr Ralf Jauch's lab in The University of Hong Kong / Centre for Translational Stem Cell Biology, the team introduced choanoflagellate Sox genes into mouse cells, replacing the native Sox2 gene achieving reprogramming towards the pluripotent stem cell state.
Once the membrane was in place, the team added human induced pluripotent stem cell derivatives into the chip.
The paper is entitled 'Naive pluripotent stem cell-based models capture FGF-dependent human hypoblast lineage specification' and is published in Cell Stem Cell.
"Lack of an authentic human BBB model has been a major hurdle in studying neurological diseases," says lead corresponding author Ziyuan Guo, PhD, "Our breakthrough involves the generation of human BBB organoids from human pluripotent stem cells, mimicking human neurovascular development to produce a faithful representation of the barrier in growing, functioning brain tissue. This is an important advance because animal models we currently use in research do not accurately reflect human brain development and BBB functionality."
Giving further insights into their research work published on 3 April 2024 in Volume 15 of Frontiers in Plant Science, Dr. Igawa says, "Instead of using external PGRs, our system uses the DR genes, which are involved in development and morphogenesis, to control cellular differentiation. The system utilizes transcription factor genes and resembles induced pluripotent cell generation in mammals."
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