peptidase

[ pep-ti-deys, -deyz ]

noun

, Biochemistry.

1. any of the class of enzymes that catalyze the hydrolysis of peptides or peptones to amino acids.

peptidase

/ -ˌdeɪz; ˈpɛptɪˌdeɪs /

noun

1. any of a group of proteolytic enzymes that hydrolyse peptides to amino acids

Word History and Origins

Origin of peptidase¹

First recorded in 1915–20; peptide + -ase

Example Sentences

And perhaps most importantly, the modifications resulted in a molecule that bound and inhibited signal peptidase in a completely novel way, overcoming known arylomycin-resistance mutations.

From Scientific American

The frequently mutated apoptosis gene CASP8 displayed clustered missense and other inactivating mutations in the first death effector, intron and caspase peptidase domains.

From Nature

We generated over a thousand new molecules until we found ones that could penetrate the outer membrane and engage the signal peptidase with exquisite affinity.

From Scientific American

Because signal peptidase is essential for bacterial survival, it’s an obvious antibiotic target.

From Scientific American

Our discovery efforts started with arylomycins, a class of molecules that target a protein called signal peptidase, which lies just beneath the outer membrane in gram-negative bacteria.

From Scientific American