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methotrexate

[ meth-oh-trek-seyt ]

noun

, Pharmacology.
  1. a toxic folic acid analogue, C 2 0 H 2 2 N 8 O 5 , that inhibits cellular reproduction, used primarily in the treatment of psoriasis and certain cancers and as an immunosuppressive agent.


methotrexate

/ ˌmɛθəʊˈtrɛkseɪt; ˌmiːθəʊ- /

noun

  1. an antimetabolite drug used in the treatment of certain cancers. Formula: C 20 H 22 N 8 O 5
“Collins English Dictionary — Complete & Unabridged” 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012


methotrexate

/ mĕth′ə-trĕksāt /

  1. A toxic drug that acts as a folic acid antagonist to interfere with cellular reproduction and is used in the treatment of psoriasis, certain cancers, and certain inflammatory diseases, such as rheumatoid arthritis. Chemical formula: C 20 H 22 N 8 O 5 .


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Word History and Origins

Origin of methotrexate1

1950–55; metho(xy)- + trexate, of unclear derivation
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Example Sentences

According to a recent statement from the Arthritis Foundation, people in states like Texas are reporting difficulties getting their prescriptions for methotrexate filled.

Soon after she started taking the drug methotrexate in February, Jennifer Crow noticed a significant improvement in her inflammatory arthritis pain.

From Time

Murphy says reports of patients being denied methotrexate are anecdotal, so it’s hard to get a handle on how common they are.

From Time

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