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megaloblast

[ meg-uh-luh-blast ]

noun

, Pathology.
  1. an abnormally large, immature, and dysfunctional red blood cell found in the blood of persons with pernicious anemia or certain other disorders.


megaloblast

/ ˈmɛɡələʊˌblɑːst; ˌmɛɡələʊˈblæstɪk /

noun

  1. an abnormally large red blood cell precursor, present in certain types of anaemia
“Collins English Dictionary — Complete & Unabridged” 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012


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Derived Forms

  • megaloblastic, adjective
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Other Words From

  • mega·lo·blastic adjective
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Word History and Origins

Origin of megaloblast1

First recorded in 1895–1900; megalo- + -blast
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Example Sentences

The normoblastic type is found most frequently, but side by side with it, megaloblasts and forms transitional between the two are occasionally found.

Professor Henry made several studies and stained a number of slides, verifying in his report the statements of the presence of megaloblasts and nucleated red cells made above.

In the conditions, which Biermer, on the grounds of their clinical peculiarities, has distinguished as "essential, pernicious anæmia" megaloblasts on the contrary occur, and represent an embryonic type of development.

All researches, which try to obscure or totally deny the distinction between megaloblasts and normoblasts are wrecked by the simple clinical fact that in pernicious anæmia the blood is megaloblastic.

The appearance of megaloblasts and megalocytes is therefore evidence that the regeneration of the blood in the bone-marrow is not proceeding in the normal manner, but in a way which approximates to the embryonic type.

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megalo-megaloblastic anaemia