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Example Sentences
Using genetic editing, the scientists showed that ETS2 was essential for almost all inflammatory functions in macrophages, including several that directly contribute to tissue damage in IBD.
About 5% of the world's population, and one in ten people in the UK1, are currently affected by an autoimmune disease, such as IBD, the umbrella term for Crohn's disease and ulcerative colitis.
These diseases are also becoming more common, with over half a million people living with IBD in the UK as of 2022, nearly double the 300,000 previously estimated2.
Despite increasing prevalence, current treatments do not work in every patient and attempts to develop new drugs often fail due to our incomplete understanding of what causes IBD.
In research published in Nature, scientists at the Crick journeyed into a 'gene desert' -- an area of DNA that doesn't code for proteins -- which has previously been linked to IBD and several other autoimmune diseases3.
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