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heavy chain

noun

, Immunology.
  1. either of an identical pair of Y -shaped polypeptides that, together with the light chains, constitute the antibody molecule.


heavy chain

noun

  1. immunol a type of polypeptide chain present in an immunoglobulin molecule
“Collins English Dictionary — Complete & Unabridged” 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012


heavy chain

/ hĕvē /

  1. The larger of the two types of polypeptide chains in an immunoglobulin molecule. A heavy chain consists of an antigen-binding portion having a variable amino acid sequence, and a constant region that is different for each class of imunoglobulin. Each heavy chain is one of a Y-shaped identical pair and is attached along its variable region to a smaller light chain.
  2. Compare light chain


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Word History and Origins

Origin of heavy chain1

First recorded in 1960–65
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Example Sentences

He was covered in dark, full-body fur, horns curling out of his head, rattling his heavy chains at my sweet little boys.

Each master wears a heavy chain collar comprised of links of different metals, each representing a different area of study.

What was his astonishment at finding an enormous padlock and a heavy chain upon the door!

I was loaded with a heavy chain, which confined my legs, my companion the same, and we were left to our fate.

He found him sitting on the bare floor, with a heavy chain around his neck, and firmly fastened at the other end into the wall.

A house at Athens was haunted by a spirit which roamed through the apartments at night, seemingly dragging a heavy chain after it.

Their wrists were manacled, and, as a further precaution, a heavy chain bound their arms to their waists.

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