endostatin

[ en-doh-stat-n ]

noun

, Biochemistry.

1. a naturally occurring protein, collagen 18, that interferes with the growth of new blood vessels: investigated for use as an anticancer drug.

Word History and Origins

Origin of endostatin¹

First recorded in 1995–2000; endo(thelial) ( def ) + -stat ( def ) + -in ²( def )

Example Sentences

Also of interest are endostatin, angiostatin and the previously mentioned thrombospondin-1.

From Scientific American

Fragments of the anticancer drug endostatin can halt fibrosis in a slab of human skin.

From Science Magazine

Scientists think that naturally produced endostatin can't counteract the accumulation of connective tissue in fibrosis patients, perhaps because another molecule inhibits it.

From Science Magazine

Cell and molecular biologist Carol Feghali-Bostwick of the University of Pittsburgh School of Medicine in Pennsylvania and colleagues decided to test whether endostatin, a drug undergoing clinical trials as a treatment for various cancers, also has an effect on fibrosis.

From Science Magazine

Endostatin is one of the so-called angiogenesis inhibitors, a group of much-touted drugs that block the formation of new blood vessels that tumors need for growth.

From Science Magazine