dacarbazine

[ duh-kahr-buh-zeen ]

noun

, Pharmacology.

1. a toxic, light-sensitive powder, C 6 H 10 N 6 O, used in the treatment of Hodgkin's disease and metastatic malignant melanoma.

Word History and Origins

Origin of dacarbazine¹

First recorded in 1960–65; contraction and rearrangement of the chemical name

Example Sentences

The combinations — Adriamycin, bleomycin, vinblastine and dacarbazine, for instance, to treat Hodgkin’s disease — were rarely changed for individual patients.

From New York Times

Average survival among people who took Halaven was 15.6 months, compared to 8.4 months among those who took another chemotherapy drug, dacarbazine.

From US News

Zelboraf led some doctors to question whether to go ahead with the trials they had planned, trials that would pit Zelboraf against the standard treatment, a chemotherapy developed in 1975 called dacarbazine.

From Reuters

Although it is unclear how researchers would predict effective combinations of therapy for certain tumours, recent clinical success of immunotherapy–chemotherapy combinations, for example ipilimumab with dacarbazine for the treatment of metastatic melanoma and vaccination with docetaxel for metastatic androgen-resistant prostate cancer, should force the further consideration of chemotherapy and immunotherapy combinations.

From Nature

The results from an abstract, or brief summary, of the study showed that Zelboraf led to a median overall survival of 13.2 months compared with 9.6 months for those who received dacarbazine chemotherapy.

From Reuters