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cross-tolerance

[ kraws-tol-er-uhns, kros- ]

noun

, Physiology.
  1. the resistance to one or more effects of a substance because of tolerance to a pharmacologically similar substance:

    a cross-tolerance of some alcoholics to anesthetics.



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Word History and Origins

Origin of cross-tolerance1

First recorded in 1920–25
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Example Sentences

The exact mechanism by which methadone works is not known, but it involves tolerance and cross-tolerance, or blockade.

Presumably because methadone works on the same brain centers as heroin, it induces a cross-tolerance to heroin and blocks its effects.

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