angiostatin

[ an-jee-oh-stat-n ]

noun

, Biochemistry.

1. a naturally occurring protein that inhibits endothelial proliferation and interferes with the growth of new blood vessels, investigated for use as an anticancer drug.

Example Sentences

Also of interest are endostatin, angiostatin and the previously mentioned thrombospondin-1.

From Scientific American

Entremed shares dropped nearly 50% at the news last Tuesday, even though the company is still planning human tests later this year--and even though Bristol-Meyers Squibb has retained the right to market angiostatin if it works out.

From Time Magazine Archive

The treatment in question, a combination of two drugs called angiostatin and endostatin, works only in mice so far, and while the newspaper noted that lots of medicines fail to make the leap from rodents to humans, the caveats were easily overlooked.

From Time Magazine Archive

Bristol-Meyers Squibb, Entremed's partner in angiostatin, said last week that it was dropping its work on the drug--not, the company emphasized, because of doubts about its potential, but because it's proving difficult to make enough of the stuff to test on humans.

From Time Magazine Archive

EntreMed claims it now has a way to make lots of endostatin, using yeast cells as tiny factories; angiostatin is proving a lot tougher to mass-produce.

From Time Magazine Archive